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Effect of Decreased Dopamine Synthesis on the Development of Hypertension Induced by Salt Loading in Spontaneously Hypertensive Rats
| Content Provider | Scilit |
|---|---|
| Author | Yoshimura, Manabu Kambara, Seichi Okabayashi, Hideoki Takahashi, Hakuo Ijichi, Hamao |
| Copyright Year | 1987 |
| Description | Journal: Clinical and Experimental Hypertension. Part A: Theory and Practice To clarify role of dopamine in the development of hypertension, the effect of a dopamine synthesis inhibitor on blood pressure and urinary output of catecholamines was investigated in spontaneously hypertensive rats (SHR) fed with high sodium diet. Rats were orally given carbidopa, an inhibitor of peripheral DOPA decarboxylase, or the vehicle for 4 weeks. Carbidopa administration accelerated significantly the development of hypertension as compared to the control SHRs with the vehicle. Carbidopa administration resulted in a significant decrease of urinary excreted sodium, urinary dopamine and renal content of dopamine. Conversely, carbidopa administration resulted in a significant increase of urinary excreted norepinephrine, urinary epinephrine and renal content of norepinephrine as compared with control SHRs. These results suggest that decreased dopamine synthesis in kidneys and probably other peripheral tissue accelerates the development of hypertension, mediated by a decrease of natriuresis and an enhancement of sympatho-adrenomedullary activity. Dopamine plays an important role in its protective action against the development of hypertension enhanced by salt loading, and decreased dopaminergic mechanisms accelerated hypertension in SHR. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10641968709160039 |
| Ending Page | 1157 |
| Page Count | 17 |
| Starting Page | 1141 |
| ISSN | 07300077 |
| DOI | 10.3109/10641968709160039 |
| Journal | Clinical and Experimental Hypertension. Part A: Theory and Practice |
| Issue Number | 7 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1987-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical and Experimental Hypertension. Part A: Theory and Practice Peripheral Vascular Disease Hypertension Spontaneously Hypertensive Rats Salt Loading |
| Content Type | Text |
| Subject | Internal Medicine |
