NDLI: Cancer stem cell and cancer stemloids: from biology to therapy.

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Cancer stem cell and cancer stemloids: from biology to therapy.

Content Provider	Scilit
Author	Blagosklonny, Mikhail V.
Copyright Year	2007
Description	Journal: Cancer Biology & Therapy It has become a cliché that cancer therapy fails because it does not target rare cancer stem cells (CSCs). Here we are discuss that this is not how therapy fails and not any cancer cell with stem-like properties is CSC. Paradoxically, CSCs must be resting to explain their resistance to therapy yet must be cycling to explain their persistence in cell culture. To solve contradictions, this article introduces the term cancer stemloids (or stem cell-like cells) to describe proliferating self-renewing cells. The stem cell hierarchy (stem--proliferating--terminal cells) exists exactly to separate self-renewal (immortality) from proliferation. Cancer stemloids break the stem cell hierarchy and eventually may replace other cells. While CSC is shielded from any selective pressure and therefore unable to drive tumor progression, cancer stemloids undergo clonal selection, accumulate mutations, thus determining tumor progression and therapeutic failures. Unlike CSC, cancer stemloids are a crucial target for cancer therapy, exactly because they proliferate. Furthermore, two normally mutually-exclusive properties (proliferation and stemness) provide a means to design therapy to kill cancer stemloids selectively without killing normal stem and non-stem cells. In contrast, true CSCs are not only a difficult, but also an insufficient and perhaps even an unnecessary therapeutic target, especially in advanced malignancies.
Related Links	http://www.tandfonline.com/doi/pdf/10.4161/cbt.6.11.5167?needAccess=true
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.6.11.5167
Journal	Cancer Biology & Therapy
Issue Number	11
Volume Number	6
Language	English
Publisher	Informa UK Limited
Publisher Date	2007-11-01
Access Restriction	Open
Subject Keyword	Journal: Cancer Biology & Therapy Cancer Therapy Proliferation Cell Culture Cancer Stemloids
Content Type	Text
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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