NDLI: The cellular and developmental biology of medulloblastoma: Current perspectives on experimental therapeutics

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The cellular and developmental biology of medulloblastoma: Current perspectives on experimental therapeutics

Content Provider	Scilit
Author	Srivastava, Vinit Krishna Nalbantoglu, Josephine
Copyright Year	2010
Description	Journal: Cancer Biology & Therapy Dysregulation of various signaling pathways that govern cerebellar development with respect to cell proliferation, growth arrest, apoptosis and differentiation has been postulated to contribute to medulloblastoma tumourigenesis. This review will highlight the unique nature of cerebellar development in terms of its derivation from two germinal matrices and significant postnatal expansion of the granule cell precursor (GCP) compartment resulting in granule cell development and migration to form the mature cerebellar cortex. The molecular signals that are critical for timely cell cycle exit and differentiation may become dysregulated leading to unrestrained cell proliferation and enhanced cell survival; indeed, changes in these molecular markers have been observed in medulloblastoma biopsy specimens. Furthermore, transgenic models that faithfully replicate these changes develop medulloblastoma that, by in large, recapitulates the clinico-histopathological features of tumours. Cellular and developmental biological approaches have contributed greatly to the current debate on the relevance of the cancer stem cell hypothesis in understanding medulloblastoma initiation and propagation. Penultimately, research findings are being translated into experimental therapeutics that target the aberrant signal transduction machinery in medulloblastoma cells and that will hopefully lead to an improved risk-benefit profile.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cbt.9.11.11785?needAccess=true
Ending Page	852
Page Count	10
Starting Page	843
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.9.11.11785
Journal	Cancer Biology & Therapy
Issue Number	11
Volume Number	9
Language	English
Publisher	Informa UK Limited
Publisher Date	2010-06-01
Access Restriction	Open
Subject Keyword	Journal: Cancer Biology & Therapy Developmental Biology
Content Type	Text
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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