NDLI: Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems

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Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems

Content Provider	Scilit
Author	Kasiński, Adam Zielińska-Pisklak, Monika Oledzka, Ewa Sobczak, Marcin
Copyright Year	2020
Description	Journal: International Journal of Nanomedicine Abstract: Among modern drug formulations, stimuli-responsive hydrogels also called “smart hydrogels” deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnetic radiation, magnetic field and biological factors. Therefore, stimuli-responsive matrices can be potentially used in tissue engineering, cell cultures and technology of innovative drug delivery systems (DDSs), releasing the active substances under the control of internal or external stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel–sol transition connected with in situ cross-linking process. Innovative smart hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances the effectiveness of tumor chemotherapy and subsequently limits systemic toxicity. External stimulus sensitivity allows remote control over the drug release profile and gel formation. On the other hand, internal factors provide drg accumulation in tumor tissue and reduce the concentration of active drug form in healthy tissue. In this report, we summarise the basic knowledge and chemical strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326401/pdf https://www.dovepress.com/getfile.php?fileID=59172
Ending Page	4572
Page Count	32
Starting Page	4541
e-ISSN	11782013
DOI	10.2147/ijn.s248987
Journal	International Journal of Nanomedicine
Volume Number	ume 15
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-06-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Biomedical Engineering Anticancer Drug Delivery Systems Controlled Release Drug Delivery Systems Smart Hydrogels Stimuli-responsive Hydrogels
Content Type	Text

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