NDLI: The lncRNA HOXA11-AS regulates Rab3D expression by sponging miR-125a-5p promoting metastasis of osteosarcoma

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The lncRNA HOXA11-AS regulates Rab3D expression by sponging miR-125a-5p promoting metastasis of osteosarcoma

Content Provider	Scilit
Author	Cao, Kun Fang, Yueyang Wang, Hao Jiang, Zheng Guo, Li Hu, Yong
Copyright Year	2019
Description	Journal: Cancer Management and Research Objective: Many studies have shown that long non-coding RNAs (lncRNAs) are closely related to various cancers. This study aims to explore the roles of lncRNA HOXA11-AS in the development and progression of osteosarcoma (OS). Methods: The expression levels of HOXA11-AS and miR-125a-5p in tumor tissues and the adjacent tissues were detected by RT-PCR method. The proliferation, migration and invasion of MG-63 and KHOS cells were determined. Results: It was found that HOXA11-AS expression levels in OS tissues and OS cell lines were higher than those in OS adjacent tissues and normal human osteoblast cell lines. The higher expression level of HOXA11-AS was positively correlated with more severe clinical stage, distant metastasis and poor prognosis of OS. Inhibition of HOXA11-AS expression could reduce metastasis and invasion of OS cell lines. In addition, HOXA11-AS was found to be an endogenous inhibitor of miR-125a-5p, it down regulated the expression level of miR-125a-5p, and this process could promote the expression of Rab3D, the target gene of miR-125a-5p. Conclusion: Our study elucidated the role of a new HOXA11-AS/miR-125a-5p/Rab3D regulatory pathway in promoting OS metastasis.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529177/pdf https://www.dovepress.com/getfile.php?fileID=49916
Ending Page	4518
Page Count	14
Starting Page	4505
ISSN	11791322
DOI	10.2147/cmar.s196025
Journal	Cancer Management and Research
Volume Number	ume 11
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-05-01
Access Restriction	Open
Subject Keyword	Journal: Cancer Management and Research Integrative and Complementary Medicine Long Non-coding Rnas (lncrnas) Osteosarcoma (os)
Content Type	Text
Subject	Oncology

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