NDLI: c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells

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c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells

Content Provider	Scilit
Author	Hahm, Eun-Ryeong Singh, Krishna Beer Singh, Shivendra V.
Copyright Year	2016
Description	Journal: Cell Cycle Honokiol (HNK), a highly promising phytochemical derived from Magnolia officinalis plant, exhibits in vitro and in vivo anticancer activity against prostate cancer but the underlying mechanism is not fully clear. This study was undertaken to delineate the role of c-Myc in anticancer effects of HNK. Exposure of prostate cancer cells to plasma achievable doses of HNK resulted in a marked decrease in levels of total and/or phosphorylated c-Myc protein as well as its mRNA expression. We also observed suppression of c-Myc protein in PC-3 xenografts upon oral HNK administration. Stable overexpression of c-Myc in PC-3 and 22Rv1 cells conferred significant protection against HNK-mediated growth inhibition and $G_{0}-G_{1}$ phase cell cycle arrest. HNK treatment decreased expression of c-Myc downstream targets including Cyclin D1 and Enhancer of Zeste Homolog 2 (EZH2), and these effects were partially restored upon c-Myc overexpression. In addition, PC-3 and DU145 cells with stable knockdown of EZH2 were relatively more sensitive to growth inhibition by HNK compared with control cells. Finally, androgen receptor overexpression abrogated HNK-mediated downregulation of c-Myc and its targets particularly EZH2. The present study indicates that c-Myc, which is often overexpressed in early and late stages of human prostate cancer, is a novel target of prostate cancer growth inhibition by HNK.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/15384101.2016.1201253?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004679/pdf
Ending Page	2320
Page Count	12
Starting Page	2309
ISSN	15384101
e-ISSN	15514005
DOI	10.1080/15384101.2016.1201253
Journal	Cell Cycle
Issue Number	17
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-09-01
Access Restriction	Open
Subject Keyword	Journal: Cell Cycle Androgen Receptor Chemoprevention Prostate Cancer
Content Type	Text
Subject	Cell Biology Developmental Biology Medicine Molecular Biology

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A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer.

Androgen receptor serine 81 mediates Pin1 interaction and activity

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