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Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey
| Content Provider | Scilit |
|---|---|
| Author | Pittman, Gary S. Wang, Xuting Campbell, Michelle R. Coulter, Sherry J. Olson, James R. Pavuk, Marian Birnbaum, Linda S. Bell, Douglas A. |
| Copyright Year | 2019 |
| Description | Journal: Epigenetics Anniston, Alabama was home to a major polychlorinated biphenyl (PCB) production facility from 1929 until 1971. The Anniston Community Health Survey I and II (ACHS-I 2005–2007, ACHS-II 2013–2014) were conducted to explore the effects of PCB exposures. In this report we examined associations between PCB exposure and DNA methylation in whole blood using EPIC arrays (ACHS-I, n = 518; ACHS-II, n = 299). For both cohorts, 35 PCBs were measured in serum. We modelled methylation versus PCB wet-weight concentrations for: the sum of 35 PCBs, mono-ortho substituted PCBs, di-ortho substituted PCBs, tri/tetra-ortho substituted PCBs, oestrogenic PCBs, and antiestrogenic PCBs. Using robust multivariable linear regression, we adjusted for age, race, sex, smoking, total lipids, and six blood cell-type percentages. We carried out a two-stage analysis; discovery in ACHS-I followed by replication in ACHS-II. In ACHS-I, we identified 28 associations (17 unique CpGs) at p ≤ 6.70E-08 and 369 associations (286 unique CpGs) at FDR p ≤ 5.00E-02. A large proportion of the genes have been observed to interact with PCBs or dioxins in model studies. Among the 28 genome-wide significant CpG/PCB associations, 14 displayed replicated directional effects in ACHS-II; however, only one in ACHS-II was statistically significant at p ≤ 1.70E-04. While we identified many novel CpGs significantly associated with PCB exposures in ACHS-I, the differential methylation was modest and the effect was attenuated seven years later in ACHS-II, suggesting a lack of persistence of the associations between PCB exposures and altered DNA methylation in blood cells. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153539/pdf |
| Ending Page | 357 |
| Page Count | 21 |
| Starting Page | 337 |
| ISSN | 15592294 |
| e-ISSN | 15592308 |
| DOI | 10.1080/15592294.2019.1666654 |
| Journal | Epigenetics |
| Issue Number | 4 |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-04-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Epigenetics Public, Environmental and Occupational Health Polychlorinated Biphenyl (pcb) Persistent Organic Pollutant (pop) 8-tetrachlorodibenzodioxin (tcdd/dioxin) Polychlorinated Dibenzo-p-dioxins (pcdds) Polychlorinated Dibenzofurans (pcdfs) Dna Methylation Anniston Community Health Survey (achs) |
| Content Type | Text |
| Subject | Medicine Molecular Biology Cancer Research |
