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Cytokine-induced killer cells co-cultured with non-cell derived targeting peptide-loaded dendritic cells induce a specific antitumor response
| Content Provider | Scilit |
|---|---|
| Author | Liu, Cuijuan Cui, Xueyuan Zhou, Dayong Li, Chunlin Zhao, Mengya Jin, Yaqing Ding, Chen Zhu, Yimin |
| Copyright Year | 2019 |
| Description | Journal: Cancer Biology & Therapy Cancer is a severe lethal disease. Currently, immunotherapy has become an effective alternative therapeutic approach for cancers. Cytokine-induced killer (CIK) cells have a higher proliferation rate, increased efficacy with few side-effects, and non-MHC-restricted killing after co-culturing with dendritic cells (DCs). Therefore, it has been widely studied and applied in the treatment of cancers. In our study, we explored the antitumor effects of CIK cells co-culturing with DCs pulsed with non-cell derived targeting peptides, which could specifically bind to certain tumor cells. Our results indicated that targeting peptide-loaded DCs could enhance the differentiation and cytotoxicity of CIK cells. Moreover, CIK cells, which were treated with specific targeting peptide-loaded DCs, could effectively and specifically kill tumor cells in vitro and in vivo, as long as tumor cells were pre-coated with the specific binding peptides. In conclusion, targeting peptides could guide DC-CIK to effectively and specifically kill tumor cells which were pre-coated with these targeting peptides and non-cell derived targeting peptide-loaded-DC-CIK may work as a novel means for cancer therapy. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606041/pdf |
| Ending Page | 728 |
| Page Count | 9 |
| Starting Page | 720 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.1080/15384047.2018.1564561 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 5 |
| Volume Number | 20 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-05-04 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Dendritic Cells Cytokine-induced Killer Cells Immunotherapy |
| Content Type | Text |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
