Loading...
Please wait, while we are loading the content...
BP1overexpression is associated with adverse prognosis inde novoacute myeloid leukemia
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Jing-Dong Yang, Jing Guo, Hong Deng, Zhao-Qun Wen, Xiang-Mei Yang, Lei Yin, Jia-Yu Xiao, Gao-Fei Lin, Jiang Qian, Jun |
| Copyright Year | 2015 |
| Description | Journal: Leukemia & Lymphoma To investigate DLX4 isoforms expression and their clinical significance in acute myeloid leukemia (AML). DLX4 transcript variant 1 (BP1) expression was significantly up-regulated in AML patients compared with normal controls. However, DLX4 transcript variant 2 (DLX7) was significantly down-regulated in AML patients. Both in the overall AML and the non-M3 AML cohorts, those patients with high BP1 expression $(BP1^{high}$) showed significantly lower rates of complete remission than those with low BP1 expression $(BP1^{low}$). $BP1^{high}$ cases had significantly shorter overall survival than $BP1^{low}$ cases in the overall AML cohort, non-M3 AML, and cytogenetically normal AML (CN-AML). Multivariate analysis confirmed the independent prognostic value of BP1 expression among both the overall AML cohort and non-M3 AML as well as CN-AML patients. However, we did not observe the impact of DLX7 expression on prognosis in AML patients. Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428194.2015.1088648 |
| Ending Page | 834 |
| Page Count | 7 |
| Starting Page | 828 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2015.1088648 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 4 |
| Volume Number | 57 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-12-23 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Medical Laboratory Technology Acute Myeloid Leukemia |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
