NDLI: Manipulation of Naproxen Particle Morphology Via the Spherical Crystallization Technique to Achieve A Directly Compressible Raw Material

Please wait, while we are loading the content...

Manipulation of Naproxen Particle Morphology Via the Spherical Crystallization Technique to Achieve A Directly Compressible Raw Material

Content Provider	Scilit
Author	Gordonx, Marc S. Chowhan, Zak T.
Copyright Year	1990
Description	Journal: Drug Development and Industrial Pharmacy Crystals of naproxen were modified by the spherical crystallization technique to improve the compression and flow characteristics of the drug substance. A naproxen:acetone solution was added to water, and the crystals were agglomerated with either hexanol, octanol, or toluene. The resulting agglomerates were compact spherical aggregates of plate shaped crystals, regardless of the agglomerating solvent used. The quantity of the agglomerating solvent and the temperature of the solvent system were critical process parameters, probably due to their effect on the drug solubilization. Crystal agglomeration sufficiently improved the intrinsic compressibility and flow characteristics of naproxen that the agglomerated material was directly compressible.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049009115961
Ending Page	1290
Page Count	12
Starting Page	1279
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049009115961
Journal	Drug Development and Industrial Pharmacy
Issue Number	8
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	1990-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Applied Chemistry Raw Materials
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in