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Novel Injectable Fluorinated Contrast Agents with Enhanced Radiopacity
| Content Provider | Scilit |
|---|---|
| Author | Sanchez, V. Zarif, L. Greiner, J. Riess, J. G. Cippolini, S. Bruneton, J. N. |
| Copyright Year | 1994 |
| Description | Journal: Artificial cells, blood substitutes, and immobilization biotechnology Novel emulsions containing iodinated fluorinated radiopaque (IFR) molecules were prepared and evaluated as injectable contrast agents with prolonged intravascular persistence. Various stable IFR/egg yolk phospholipid emulsions were produced, heat-sterilized, and tested as to their radiopacity, shelf-stability and in vivo tolerance. No significant change in mean particle sizes was observed over a 3-month storage period at 40 degrees C. Intravenous injection of an emulsion of a 0.39 g/kg bw dose of a typical IFR, C6F13CH = CIC6H13 (F6H6IE) in rabbits led to high contrast in the liver and spleen. The same radiopacity of the liver was achieved with 7 times less IFR than perfluorooctyl bromide. Histological examination after 24 h, and blood analysis after 24, 48 h and 7 days, demonstrated normal functioning of the liver, even when high concentrations of IFR were present. The neat IFR was tolerated i.p. in mice at a 45 g/kg bw dose. Emulsified IFR was tolerated in rats and mice i.v. at a 8 g/kg bw dose. The iodinated fluorinated molecule tested appears promising for the formulation of new contrast agents for diagnosis. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10731199409138846 |
| Ending Page | 1428 |
| Page Count | 8 |
| Starting Page | 1421 |
| ISSN | 10731199 |
| e-ISSN | 15324184 |
| DOI | 10.3109/10731199409138846 |
| Journal | Artificial cells, blood substitutes, and immobilization biotechnology |
| Issue Number | 4 |
| Volume Number | 22 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Artificial cells, blood substitutes, and immobilization biotechnology Iodinated Fluorinated |
| Content Type | Text |
| Subject | Biomedical Engineering Biotechnology |
