NDLI: Herpetic Vestibular Neuritis: An Experimental Study

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Herpetic Vestibular Neuritis: An Experimental Study

Content Provider	Scilit
Author	Hirata, Yoshinari Gyo, Kiyofumi Yanagihara, Naoaki
Copyright Year	1995
Description	Journal: Acta Oto-Laryngologica An animal model of vestibular neuritis was developed by inoculating herpes simplex virus type 1 (HSV-1) into the auricle of mice. Postural deviation was observed in 5 of 99 mice at 6 to 8 days after inoculation. Following evaluation of the vestibular function, the animals were sacrificed and the vestibular nerves examined for histopathology and immunohistochemically. All mice developed postural deviation, presented as abnormal behaviour; they could not perform various vestibular tasks, such as gait, traversing a narrow path, climbing a rope, negative geotaxis, grasping a rod, and swimming. Degeneration of Scarpa's ganglion was observed in 4 of 5 mice that developed postural deviation, while HSV-1 antigens were found in 2 of them. No such histological findings were seen in animals with normal vestibular function.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00016489509121878
Ending Page	96
Page Count	4
Starting Page	93
ISSN	00016489
e-ISSN	16512251
DOI	10.3109/00016489509121878
Journal	Acta Oto-Laryngologica
Issue Number	sup519
Volume Number	115
Language	English
Publisher	Informa UK Limited
Publisher Date	1995-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oto-Laryngologica Otorhinolaryngology
Content Type	Text
Subject	Otorhinolaryngology

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