NDLI: Virus-like particles as universal influenza vaccines

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Virus-like particles as universal influenza vaccines

Content Provider	Scilit
Author	Kang, Sang-Moo Kim, Min-Chul Compans, Richard
Copyright Year	2012
Description	Journal: Expert Review of Vaccines Current influenza vaccines are primarily targeted to induce immunity to the influenza virus strain-specific hemagglutinin antigen and are not effective in controlling outbreaks of new pandemic viruses. An approach for developing universal vaccines is to present highly conserved antigenic epitopes in an immunogenic conformation such as virus-like particles (VLPs) together with an adjuvant to enhance the vaccine immunogenicity. In this review, the authors focus on conserved antigenic targets and molecular adjuvants that were presented in VLPs. Conserved antigenic targets that include the hemagglutinin stalk domain, the external domain of influenza M2 and neuraminidase are discussed in addition to molecular adjuvants that are engineered to be incorporated into VLPs in a membrane-anchored form.
Related Links	http://europepmc.org/articles/pmc3513402?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513402/pdf
ISSN	14760584
e-ISSN	17448395
DOI	10.1586/erv.12.70
Journal	Expert Review of Vaccines
Issue Number	8
Volume Number	11
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-08-01
Access Restriction	Open
Subject Keyword	Journal: Expert Review of Vaccines Ha Stalk Domain Universal Vaccine
Content Type	Text
Subject	Drug Discovery Pharmacology Immunology Molecular Medicine

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