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Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study
| Content Provider | Scilit |
|---|---|
| Author | Wang, Haixia Bai, Chenxiao Yi, Mo Jia, Yuanmin Li, Yizhang Jiang, Di Chen, Ou |
| Copyright Year | 2020 |
| Description | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Background: Although metabolic syndrome is awell-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial. Objective: The aim of this study was to explore the associations of metabolic syndrome and its components with incident asthma in Chinese adults. Methods: We conducted an open cohort study of participants who were asthma-free at baseline (n=42,304) in the Shandong multi-center health check-up longitudinal study from 2004 to 2015. Participants aged ≥ 20 years and had regular physical examination (once ayear) more than three times during follow-up. Results: Ninety subjects (38 women and 52 men) developed incident asthma over 12 years of follow-up. Our study suggested that metabolic syndrome itself was not significantly associated with incident asthma in either women or men (P> 0.050). Interestingly, we found that overweight and/or obesity was arisk factor for incident asthma among women but not men in the Cox proportional hazards model after adjusting covariates (adjusted incidence rate ratio (IRR)= 2.940, 95% confidence interval (CI): 1.467– 5.894, P=0.002). The result was consistent with the Poisson regression model (hazard ratio (HR)= 2.241, 95% CI: 1.135– 4.988, P=0.026). After stratifying according to overweight and/or obesity, we found that female subjects with overweight and obesity were associated with the occurrence of incident asthma (P< 0.050). However, we did not find this result among men. Conclusion: Metabolic syndrome was not significantly associated with incident asthma in both women and men; however, overweight and/or obesity was shown to be asignificant risk factor for incident asthma but only in women, not in men. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532911/pdf https://www.dovepress.com/getfile.php?fileID=61919 |
| Ending Page | 3420 |
| Page Count | 10 |
| Starting Page | 3411 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s274159 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | ume 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Womens Studies Overweight And/or Obesity Metabolic Syndrome Incident Asthma |
| Content Type | Text |
| Subject | Internal Medicine Pharmacology |
