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IgG for Intravenous Use, Autologous Serum and Plasma Induce Comparable Interleukin-1 Receptor Antagonist Liberation from Human Mononuclear Cells: AnIn VitroPhenomenon Depending upon Plastic Adherence
| Content Provider | Scilit |
|---|---|
| Author | Andersen, Lis Smedegaard Petersen, Jørgen Svenson, Morten Bendtzen, Klaus |
| Copyright Year | 1995 |
| Description | Journal: Autoimmunity Immunoglobulin G (IgG) for intravenous use (IVIg) selectively stimulates production of interleukin-1 receptor antagonist protein (IL-1ra) by mononuclear cells in vitro and has been proposed to stimulate IL-1ra production in vivo as part of the therapeutic effect. We tested if IVIg differed from human IgG-containing media (i.e., autologous serum (HS) and plasma (HP)) in stimulating IL-1ra release by MNC in vitro and whether IVIg induced a delayed increase in serum levels of IL-1ra. IVIg, 0.01–0.5 mg/ml, increased the IL-1ra liberation from MNC 10–15 times over that of untreated controls. HP and HS (5% v/v) had comparable effects. However, the stimulated IL-1ra liberation was reduced to less than twice the background liberation when fetal calf serum (FCS)-precoated tubes were used. Three days of high-dose IgG infusion had no significant effect on the serum levels of IL-1ra. It is concluded that therapeutic effects of IVIg cannot be ascribed to significant stimulation of IL-1ra production in vivo, as previously suggested, and that the observed stimulation of IL-1ra production in vitro is an epiphenomenon strictly dependent upon adherence of human serum and plasma constituents. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/08916939508995309 |
| Ending Page | 133 |
| Page Count | 7 |
| Starting Page | 127 |
| ISSN | 08916934 |
| e-ISSN | 1607842X |
| DOI | 10.3109/08916939508995309 |
| Journal | Autoimmunity |
| Issue Number | 2 |
| Volume Number | 22 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1995-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Autoimmunity Cell Tissue Engineering Stimulation of Il 1ra Production |
| Content Type | Text |
| Subject | Immunology and Allergy Immunology |
