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Volume Regulation in Guinea Pig Outer Hair Cells and the Role of Intracellular Calcium
| Content Provider | Scilit |
|---|---|
| Author | Harada, Narinobu Ernst, Arne Zenner, Hans Peter |
| Copyright Year | 1993 |
| Description | Journal: Acta Oto-Laryngologica Single outer hair cells (OHCs) isolated from the guinea pig cochlea showed a regulatory volume decrease (RVD) after the initial cells swelling despite continued exposure to a hypotonic solution. The accompanying change of the intracellular $Ca^{2+}$ concentration $([Ca^{2+}$]i) in the OHCs was investigated using the $Ca^{2+}$-sensitive dye fura-2. Hyposmotic activation led to a $[Ca^{2+}$]i increase which was accompanied by cell shortening and swelling. In a nominally $Ca^{2+}$ -free solution, however, $[Ca^{2+}$]i was not significantly increased during hyposmotic activation although shortening and swelling of the OHCs were observed. These results suggest that the increase in $[Ca^{2+}$]i during hyposmotic activation is mainly based on an influx of extracellular $Ca^{2+}$. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/00016489309126176 |
| Ending Page | 41 |
| Page Count | 3 |
| Starting Page | 39 |
| ISSN | 00016489 |
| e-ISSN | 16512251 |
| DOI | 10.3109/00016489309126176 |
| Journal | Acta Oto-Laryngologica |
| Issue Number | sup500 |
| Volume Number | 113 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1993-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oto-Laryngologica Cell Tissue Engineering Volume Regulation Outer Hair Cell Hyposmotic Activation. |
| Content Type | Text |
| Subject | Otorhinolaryngology |
