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Evaluation of a Modified Paddle Method for Dissolution Testing
| Content Provider | Scilit |
|---|---|
| Author | Shenouda, L. S. Adams, K. A. Alcorn, G. J. Zoglio, M. A. |
| Copyright Year | 1986 |
| Description | Journal: Drug Development and Industrial Pharmacy A modification of the U.S.P. paddle method for dissolution was evaluated. A 10-mesh size circular stainless steel screen was placed at the bottom of the dissolution vessel establishing an elevated platform for the tablet. The modified method was compared with the U.S.P. paddle and basket methods utilizing three different tablet formulations of the nondisintigratiny type. Two tablet formulations contained a gel forming material hydroxypro-pylmethylcellulose K-4000 and the third tablet formulation has tricalcium phosphate as the major filler. The active ingredients were either dyphylline or melperone HCl. The data were evaluated by a one-way analysis of variance combined with Ryan-Einot-Gabriel-Welsch multiple F-test for comparison between methods. The results suggest that the proposed modified paddle method for dissolution may provide the formulator with an alternative for evaluating release of drugs from solid dosage forms containing swell able gums. This method offers the advantages of continuous visual monitoring of the dosage form to ascertain its integrity and full exposure of the total surface area of the tablet without sticking to the walls of the dissolution vessel |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048609065856 |
| Ending Page | 1239 |
| Page Count | 13 |
| Starting Page | 1227 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048609065856 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 8-9 |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1986-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Anesthesiology Paddle Method Modified Paddle Dissolution Testing Method for Dissolution |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
