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Breaking bad habits: Targeting MDSCs to alleviate immunosuppression in prostate cancer
| Content Provider | Scilit |
|---|---|
| Author | Pal, Sumanta K. Kortylewski, Marcin |
| Copyright Year | 2015 |
| Description | Journal: OncoImmunology The myeloid-derived suppressor cells (MDSCs) contribute to tumor immune evasion and still remain an elusive therapeutic target. Our study identified granulocytic MDSCs accumulating in prostate cancer patients during disease progression. We demonstrate the feasibility of using STAT3siRNA-based strategy for targeting MDSCs to alleviate arginase-dependent suppression of T cell activity. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.1080/2162402X.2015.1078060?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801434/pdf |
| e-ISSN | 2162402X |
| DOI | 10.1080/2162402X.2015.1078060 |
| Journal | OncoImmunology |
| Issue Number | 2 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-06-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: OncoImmunology Research and Experimental Medicine Immunotherapy Myeloid-derived Suppressor Cells Prostate Cancer |
| Content Type | Text |