NDLI: Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia

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Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia

Content Provider	Scilit
Author	Carneiro, Benedito A. Kaplan, Jason Altman, Jessica K. Giles, Francis J. Platanias, Leonidas C.
Copyright Year	2015
Description	Journal: Cancer Biology & Therapy An accumulating understanding of the complex pathogenesis of acute myeloid leukemia (AML) continues to lead to promising therapeutic approaches. Among the key aberrant intracellular signaling pathways involved in AML, the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) axis is of major interest. This axis modulates a wide array of critical cellular functions, including proliferation, metabolism, and survival. Pharmacologic inhibitors of components of this pathway have been developed over the past decade, but none has an established role in the treatment of AML. This review will discuss the preclinical data and clinical results driving ongoing attempts to exploit the PI3K/AKT/mTOR pathway in patients with AML and address issues related to negative feedback loops that account for leukemic cell survival. Targeting the PI3K/AKT/mTOR pathway is of high interest for the treatment of AML, but combination therapies with other targeted agents may be needed to block negative feedback loops in leukemia cells.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/15384047.2015.1026510?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622839/pdf
Ending Page	656
Page Count	9
Starting Page	648
ISSN	15384047
e-ISSN	15558576
DOI	10.1080/15384047.2015.1026510
Journal	Cancer Biology & Therapy
Issue Number	5
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-03-18
Access Restriction	Open
Subject Keyword	Journal: Cancer Biology & Therapy Acute Myeloid Leukemia Histone Deacetylase Mapk-interacting Kinase Phosphoinositide-dependent Protein Kinase-1 Phosphatidylinositol 3-kinase Mammalian Target of Rapamycin Targeted Therapy
Content Type	Text
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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