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Analysis of toxicology data with covariates specific to each observation

Content Provider	Scilit
Author	Geys, Helena Molenberghs, Geert Williams, Paige
Copyright Year	2002
Description	Journal: Journal of Agricultural, Biological and Environmental Statistics The standard approach for analysis of teratology studiesis to use a population-averaged model with primary interest on evaluating dose-response effects. For example, generalized estimating equations (GEEs) have become popular for analysis of both developmental toxicity and reproducti vestudies (Ryan 1992). Such an approach is typically appropriate since the covariate of interest—exposure level—is constant for each litter of animals. Recently, however, there has been growing interest in evaluating effects of covariates that can vary between individuals within a cluster. This article explores several opportunities generated by teratology studies with individual-level covariates both in terms of modeling approaches and in decomposition of litter effects into genetic and environmental components.
Related Links	http://link.springer.com/content/pdf/10.1198%2F10857110260141229.pdf
Ending Page	190
Page Count	15
Starting Page	176
ISSN	10857117
e-ISSN	15372693
DOI	10.1198/10857110260141229
Journal	Journal of Agricultural, Biological and Environmental Statistics
Issue Number	2
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2002-06-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Agricultural, Biological and Environmental Statistics Cluster Specific Correlated Binary Data Developmental Toxicology Generalized Estimating Equations Marginal Model Population Averaged
Content Type	Text
Subject	Applied Mathematics Statistics and Probability Environmental Science Agricultural and Biological Sciences Statistics, Probability and Uncertainty

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