NDLI: Toxic Effects of Antiepileptic Drugs on Immunoglobulin Gene Expression

Please wait, while we are loading the content...

Toxic Effects of Antiepileptic Drugs on Immunoglobulin Gene Expression

Content Provider	Scilit
Author	Tittle, Thomas V. Schaumann, Blanka A.
Copyright Year	1992
Description	Journal: Immunopharmacology and Immunotoxicology Murine myeloma cells were exposed to toxic, growth-retarding levels of two antiepileptic drugs (AEDs2), phenytoin (PHT) and carbamazepine (CBZ). J558L cells were treated for 12 days, washed free of drug and, upon recovery of growth, cloned to determine the frequency of lambda light chain secreting lines. Our results indicate that short-term exposure to high, toxic levels (5-10 times the therapeutic dose) of PHT and CBZ reduces or eliminates lambda light chain secretion at a high frequency. Furthermore, although most cloned lines tested positive for cytoplasmic lambda light chain, some lines had no detectable cytoplasmic immunoglobulin (Ig). The data are consistent with the hypothesis that long-term changes in fully differentiated B cell function may occur after toxic level AED exposure.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08923979209009225
Ending Page	293
Page Count	11
Starting Page	283
ISSN	08923973
e-ISSN	15322513
DOI	10.3109/08923979209009225
Journal	Immunopharmacology and Immunotoxicology
Issue Number	1-2
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	1992-01-01
Access Restriction	Open
Subject Keyword	Journal: Immunopharmacology and Immunotoxicology Immunoglobulin Antiepileptic Drugs Lines Tested Lambda Light
Content Type	Text
Subject	Immunology and Allergy Toxicology Pharmacology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in