NDLI: Chronobiological Studies on the Hypotensive Effect of Prostaglandin E2and Arachidonic Acid in the Rat

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Chronobiological Studies on the Hypotensive Effect of Prostaglandin E2and Arachidonic Acid in the Rat

Content Provider	Scilit
Author	D'auteuil, Claire Doré, François Labrecque, Gaston Bélanger, Pierre-M
Copyright Year	1984
Description	Journal: Chronobiology international The present study was designed to determine whether biological rhythm variations could be detected in the hypotensive action of prostaglandin E2 (PGE2) and arachidonic acid (AA) in normal rats. Doses of 1.0 μg kg−1 of PGE2 or 0.5 mg kg−1 of AA were administered to pentobarbital-anesthetized rats at 6 times of the day. Maximal reduction of systolic and diastolic blood pressures was obtained when PGE2 or AA were administered to rats between 0930 and 1200. The lowest falls in blood pressure were found when the same doses of the two substances were injected between 0300 and 0500. Mechanisms to explain these circadian variations are suggested.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/07420528409063907
Ending Page	277
Page Count	5
Starting Page	273
ISSN	07420528
e-ISSN	15256073
DOI	10.3109/07420528409063907
Journal	Chronobiology international
Issue Number	4
Volume Number	1
Language	English
Publisher	Informa UK Limited
Publisher Date	1984-01-01
Access Restriction	Open
Subject Keyword	Journal: Chronobiology international Anesthesiology Arachidonic Acid Prostaglandin Hypotensive Effect Chronobiological Studies E2and Arachidonic
Content Type	Text
Subject	Physiology Physiology (medical)

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