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The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis
| Content Provider | Scilit |
|---|---|
| Author | Korpal, Manav Kang, Yibin |
| Copyright Year | 2008 |
| Description | Journal: RNA Biology MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/rna.5.3.6558?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532896/pdf |
| Ending Page | 119 |
| Page Count | 5 |
| Starting Page | 115 |
| ISSN | 15476286 |
| e-ISSN | 15558584 |
| DOI | 10.4161/rna.5.3.6558 |
| Journal | RNA Biology |
| Issue Number | 3 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2008-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: RNA Biology Biochemistry and Molecular Biology Epithelial-mesenchymal Transition |
| Content Type | Text |
| Subject | Cell Biology Molecular Biology |
