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Green Synthesis and Characterization of Carboxymethyl Cellulose Fabricated Silver-Based Nanocomposite for Various Therapeutic Applications
| Content Provider | Scilit |
|---|---|
| Author | Asghar, Muhammad Arif Yousuf, Rabia Ismail Shoaib, Muhammad Harris Zehravi, Mehrukh Rehman, Ahad Abdul Imtiaz, Muhammad Suleman Khan, Kamran |
| Copyright Year | 2021 |
| Description | Journal: International Journal of Nanomedicine Purpose: The current study proposed the simple, eco-friendly and cost-effective synthesis of carboxymethyl cellulose (CMC) structured silver-based nanocomposite (CMC-AgNPs) using Syzygium aromaticum buds extract. Methods: The CMC-AgNPs were characterized by ultraviolet (UV) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transmission infra-red (FTIR), energy-dispersive X-ray (EDX), and dynamic light scattering (DLS) techniques. The synthesized nanocomposites were evaluated for their bactericidal kinetics, in-vivo anti-inflammatory, anti-leishmaniasis, antioxidant and cytotoxic activities using different in-vitro and in-vivo models. Results: The spherical shape nanocomposite of CMC-AgNPs was synthesized with the mean size range of 20– 30 nm, and the average pore diameter is 18.2 nm while the mean zeta potential of − 31.6 ± 3.64 mV. The highly significant (P Leishmania major counts decreased up to 36.7% within 24 h, and the $IC_{50}$ was found to be 28.41 μg/mL. The potent DPPH radical scavenging potential was also observed for CMC-AgNPs with the $IC_{50}$ value of 112 μg/mL. Furthermore, the cytotoxicity was assessed using HeLa cell lines with the $LC_{50}$ of 108.2 μg/mL. Conclusion: The current findings demonstrate positive attributes of CMC fabricated AgNPs as a promising antibacterial, anti-inflammatory, anti-leishmaniasis, and antioxidant agent with low cytotoxic potential. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=72533 |
| Ending Page | 5393 |
| Page Count | 23 |
| Starting Page | 5371 |
| e-ISSN | 11782013 |
| DOI | 10.2147/ijn.s321419 |
| Journal | International Journal of Nanomedicine |
| Volume Number | ume 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Nanomedicine Integrative and Complementary Medicine Silver Nanoparticles Syzygium Aromaticum Carboxymethyl Cellulose Green Synthesis Biological Applications |
| Content Type | Text |
