Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics

Content Provider	Scilit
Author	Carlander, Ulrika Moto, Tshepo Paulsen Desalegn, Anteneh Assefa Yokel, Robert A. Johanson, Gunnar
Copyright Year	2018
Description	Journal: International Journal of Nanomedicine
Abstract	Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics Ulrika Carlander,1 Tshepo Paulsen Moto,2 Anteneh Assefa Desalegn,1 Robert A Yokel,3 Gunnar Johanson1 1Unit of Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden; 2Faculty of Health Sciences, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa; 3Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA Background: Cerium dioxide nanoparticles (nanoceria) are increasingly being used in a variety of products as catalysts, coatings, and polishing agents. Furthermore, their antioxidant properties make nanoceria potential candidates for biomedical applications. To predict and avoid toxicity, information about their biokinetics is essential. A useful tool to explore such associations between exposure and internal target dose is physiologically based pharmacokinetic (PBPK) modeling. The aim of this study was to test the appropriateness of our previously published PBPK model developed for intravenous (IV) administration when applied to various sizes of nanoceria and to exposure routes relevant for humans. Methods: Experimental biokinetic data on nanoceria (obtained from various exposure routes, sizes, coatings, doses, and tissues sampled) in rats were collected from the literature and also obtained from the researchers. The PBPK model was first calibrated and validated against IV data for 30 nm citrate coated ceria and then recalibrated for 5 nm ceria. Finally, the model was modified and tested against inhalation, intratracheal (IT) instillation, and oral nanoceria data.Results: The PBPK model adequately described nanoceria time courses in various tissues for 5 nm ceria given IV. The time courses of 30 nm ceria were reasonably well predicted for liver and spleen, whereas the biokinetics in other tissues were not well captured. For the inhalation, IT instillation, and oral exposure routes, re-optimization was difficult due to low absorption and, hence, low and variable nanoceria tissue levels. Moreover, the nanoceria properties and exposure conditions varied widely among the inhalation, IT instillation, and oral studies, making it difficult to assess the importance of different factors. Conclusion: Overall, our modeling efforts suggest that nanoceria biokinetics depend largely on the exposure route and dose. Keywords: biodistribution, cerium dioxide, inhalation, instillation, intravenous, oral
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936012/pdf https://www.dovepress.com/getfile.php?fileID=41853
Ending Page	2646
Page Count	16
Starting Page	2631
e-ISSN	11782013
DOI	10.2147/ijn.s157210
Journal	International Journal of Nanomedicine
Volume Number	ume 13
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-05-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Biodistribution Cerium Dioxide Instillation
Content Type	Text