NDLI: Free Radical Mediated Cytotoxicity of Desferrioxamine

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Free Radical Mediated Cytotoxicity of Desferrioxamine

Content Provider	Scilit
Author	Poot, Martin Rabinovitch, Peter S. Hoehn, Holger
Copyright Year	1989
Description	Journal: Free radical research communications Toxic effects of desferrioxamine (DFO) upon cell growth were assayed with continuous bromodeoxyuridine (BrdU) labeling and bivariate ethidium bromide/Hoechst 33258 flow cytometry. At 5% oxygen DFO caused a dose-dependent inhibition of cell growth, which was potentiated at 20% oxygen, and by cumene hydroperoxide but not by paraquat. An irreversible arrest in the G2 phase of the cell cycle was the cell-kinetic mechanism underlying this growth inhibition. The G2 arrest was not dependent upon the BrdU concentration in the medium, thus ruling out a direct attack of a free radical on thymidine residues. The observed cytotoxicity of DFO cautions against its use in the treatment of conditions of elevated oxidative stress.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/10715768909055158
Ending Page	328
Page Count	6
Starting Page	323
ISSN	87550199
DOI	10.3109/10715768909055158
Journal	Free radical research communications
Issue Number	5
Volume Number	6
Language	English
Publisher	Informa UK Limited
Publisher Date	1989-01-01
Access Restriction	Open
Subject Keyword	Journal: Free radical research communications Cytotoxicity Free Radical Desferrioxamine
Content Type	Text
Subject	Biochemistry

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