Predictive value of [18F]fluoro-2-deoxy-d-glucose positron emission tomography for clinical outcome in patients with relapsed/refractory diffuse large B-cell lymphoma prior to and after autologous stem cell transplant

Content Provider	Scilit
Author	Qiao, Wenli Zhao, Jinhua Xing, Yan Wang, Chun Wang, Taisong
Copyright Year	2013
Description	Journal: Leukemia & Lymphoma We evaluated the predictive value of $[^{18}$F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) for clinical outcome such as progression-free survival (PFS) and overall survival (OS) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) prior to and after autologous stem cell transplant (ASCT). FDG-PET/computed tomography (CT) was performed in 39 consecutive patients with relapsed/refractory DLBCL scheduled for ASCT. The median follow-up of surviving patients was 3 years (range 19–66 months). Both pre- and post-ASCT, FDG-PET findings were strongly correlated with PFS and OS (p < 0.005). The 2-year PFS estimates for FDG-negative versus -positive patients were 84.8% vs. 36.8% (pre-) and 81.1% vs. 13.3% (post-). The 2-year OS estimates in these groups were 95.5% vs. 68.3% (pre-) and 92.7% vs. 57.1% (post-). Patients were classified into three groups according to FDG-PET results before and after ASCT. The median PFS was significantly lower in the +/+ group (13.0 months) as compared with the +/− group (31.0 months, p = 0.021) and the −/− group (p = 0.000). The regression model showed that the predictive value of FDG-PET before ASCT owed its significance to a very high hazard ratio between patients with positive and negative imaging (p < 0.01). FDG-PET prior to and following ASCT in patients with relapsed or refractory DLBCL contains prognostic information on long-term clinical outcome.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/10428194.2013.797974
Ending Page	282
Page Count	7
Starting Page	276
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2013.797974
Journal	Leukemia & Lymphoma
Issue Number	2
Volume Number	55
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-06-05
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Positron Emission Tomography Fluorine-18-fluorodeoxyglucose Diffuse Large B-cell Lymphoma Autologous Stem Cell Transplant Progression-free Survival
Content Type	Text
Subject	Hematology Cancer Research Oncology