NDLI: A Comparison of diffuse Reflectance Ft-Ir Spectroscopy and Dsc in the Characterization of a Drug-Excipient Interaction

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A Comparison of diffuse Reflectance Ft-Ir Spectroscopy and Dsc in the Characterization of a Drug-Excipient Interaction

Content Provider	Scilit
Author	Hartauer, K. J. Guillory, J. K.
Copyright Year	1991
Description	Journal: Drug Development and Industrial Pharmacy Differential scanning calorimetry (DSC) and diffuse reflectance Fourier transform infrared spectroscopy (FT-IR) were employed for the characterization of the well-known interaction between aminophylline and lactose. Brown discoloration appears in samples containing 1:5 (w/w) mixtures of aminophylline and lactose following three weeks of storage at 60°C. DSC thermograms can be used to predict that such an interaction will occur, but provide little insight into the nature of the interaction. Using FT-IR, it was possible to show that the discoloration is due to a chemical reaction between ethylenediamine and lactose.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049109044268
Ending Page	630
Page Count	14
Starting Page	617
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049109044268
Journal	Drug Development and Industrial Pharmacy
Issue Number	4
Volume Number	17
Language	English
Publisher	Informa UK Limited
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Spectroscopy Ir Spectroscopy Excipient Interaction Reflectance Ft Drug Excipient Diffuse Reflectance
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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