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Controlled Theophylline Release from Microcapsules of Acrylic & Methacrylic Acid Ester Copolymer
| Content Provider | Scilit |
|---|---|
| Author | Chattaraj, Sarat C. Das, Sudip K. Karthikeyan, M. Ghosal, Saroj K. Gupta, Bijan K. |
| Copyright Year | 1991 |
| Description | Journal: Drug Development and Industrial Pharmacy The goal of this work was to develop a suitable method for microencapsulation of theophylline using copolymer of acrylate and methacrylate ester (EUDRAGIT) as the coating material. The effect of protective colloids on the process of microencapsulation was evaluated. The in vitro studies revealed significant control of drug release for the developed dosage form. Individually, the polymer coated drug particles of different core: coat ratio and different proportions of protective colloids were found to influence the pharmacokinetic parameters as revealed from the in vivo bioavailability studies in gastric-emptying controlled rabbits. In vivo bioavailability data were compared using Westlake's confidence limit. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049109044262 |
| Ending Page | 560 |
| Page Count | 10 |
| Starting Page | 551 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049109044262 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 4 |
| Volume Number | 17 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Microcapsules Controlled Theophylline Theophylline Release Methacrylic Acid Ester Copolymer |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
