NDLI: Innate and Adaptive Immune Dysfunction and Necrotizing Enterocolitis

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Innate and Adaptive Immune Dysfunction and Necrotizing Enterocolitis

Content Provider	Scilit
Author	Osterhout, Paula Kim, Christina S. Claud, Erika C.
Copyright Year	2021
Description	Development of necrotizing enterocolitis (NEC) may be related to the interaction of an immature gut with colonizing intestinal bacteria. The innate and adaptive immune systems allow for appropriate interface with the intestinal microbiota, specifically colonization with commensal organisms and protection against pathogens. The immature intestinal barrier of a preterm infant may have increased contact with the intestinal microbiota secondary to delayed peristalsis, decreased gastric acid production, and immaturities of the intestinal epithelial barrier. An immature cellular response to intestinal microbiota increases the inflammatory response to both commensal and pathogenic organisms. Human milk and probiotics may contribute to protection against NEC by compensating for immune dysfunction found in the preterm gut. Book Name: Necrotizing Enterocolitis
Related Links	https://content.taylorfrancis.com/books/download?dac=C2018-0-86890-6&isbn=9780429288302&doi=10.1201/9780429288302-40&format=pdf
Ending Page	214
Page Count	7
Starting Page	208
DOI	10.1201/9780429288302-40
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-02-17
Access Restriction	Open
Subject Keyword	Book Name: Necrotizing Enterocolitis Pediatrics and Child Health Colonization Enterocolitis
Content Type	Text
Resource Type	Chapter

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