NDLI: Double-Blind Placebo-Controlled Trial of Fluoxetine in Smoking Cessation Treatment Including Nicotine Patch and Cognitive-Behavioral Group Therapy

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Double-Blind Placebo-Controlled Trial of Fluoxetine in Smoking Cessation Treatment Including Nicotine Patch and Cognitive-Behavioral Group Therapy

Content Provider	Scilit
Author	Saules, Karen K. Schuh, Leslie M. Arfken, Cynthia L. Reed, Karen Kilbey, M. Marlyne Schuster, Charles R.
Copyright Year	2004
Description	Journal: The American Journal on Addictions Smoking cessation attempts are often complicated by dysphoria/depression, weight gain, craving, and other nicotine withdrawal symptoms. Fluoxetine's antidepressant and anorectant properties, along with its capacity to attenuate compulsive behavior, suggest that this medication might facilitate smoking cessation treatment. We examined the effect of fluoxetine on smoking cessation in the context of a program that included group cognitive‐behavioral therapy (six weeks) and transdermal nicotine patch (ten weeks). In a double‐blind randomized trial of fluoxetine for smoking cessation, 150 daily smokers were assigned to placebo (n = 48), 20 mg (n = 51), or 40 mg fluoxetine (n = 51). Fluoxetine did not significantly improve smoking cessation rates, either for those with or without major depressive disorder (MDD) histories or elevated current depression. Our results suggest that fluoxetine may moderate withdrawal symptoms, even if that was not manifested in improved smoking cessation rates. Our results, however, clearly favor the use of fluoxetine if weight gain is a major clinical obstacle to smoking cessation.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1080/10550490490512762
Ending Page	446
Page Count	9
Starting Page	438
e-ISSN	15210391
DOI	10.1080/10550490490512762
Journal	The American Journal on Addictions
Issue Number	5
Volume Number	13
Language	English
Publisher	Informa UK Limited
Publisher Date	2004-01-01
Access Restriction	Open
Subject Keyword	Journal: The American Journal on Addictions Clinical Psychology Smoking Cessation
Content Type	Text

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