Approaching Cancer Therapy with Ruthenium Complexes by Their Interaction with DNA

Content Provider	Scilit
Author	Kumari, Niraj Mishra, Lallan
Copyright Year	2018
Description	This chapter discusses several facets of ruthenium complexes with greater emphasis on the cytotoxicity correlated with their binding with DNA and subsequently DNA cleavage. The advantage of using ruthenium in the development of metal-based antitumor drugs has been considered in a number of excellent reviews. Briefly, the benefits of exploiting ruthenium include a well-developed preparative coordination chemistry of this transition metal, providing reliable routes to novel compounds; a rate of ligand exchange often comparable to that of platinum or which can be tuned by coordination of appropriate ancillary ligands. Studies of medicinal applications of ruthenium complexes have been facilitated by the wide diversity of the coordination and organometallic chemistry of ruthenium. Dimethyl sulfoxide complexes of both ruthenium(II) and ruthenium(III) exhibit antitumor activity comparable to cisplatin at equitoxic dosage in animal models of metastasizing tumors, but with less severe side effects and prolonged host survival times. Book Name: Ruthenium Chemistry
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781315110585-8&type=chapterpdf
Ending Page	303
Page Count	45
Starting Page	259
DOI	10.1201/9781315110585-8
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-01-17
Access Restriction	Open
Subject Keyword	Book Name: Ruthenium Chemistry Inorganic Chemistry Ruthenium Complexes Survival Diversity Models Coordination Antitumor Dna and Subsequently
Content Type	Text
Resource Type	Chapter