NDLI: INTERLEUKIN-1 BETA AND TUMOR NECROSIS FACTOR-ALPHA IN NORMAL/INFERTILE MEN

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INTERLEUKIN-1 BETA AND TUMOR NECROSIS FACTOR-ALPHA IN NORMAL/INFERTILE MEN

Content Provider	Scilit
Author	Papadimas, J. Goulis, D. G. Sotiriades, A. Daniilidis, M. Fleva, A. Bontis, J. N. Tourkantonis, A.
Copyright Year	2002
Description	Journal: Archives of andrology Cytokines play an important role in intercellular communications. Human sperm contains a wide spectrum of cytokines. such as interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha). Their effects on semen quality are subject to debate. The aim of this study was to determine concentrations of IL-1beta and TNF-alpha in normal fertile men and in different groups of male infertility in an attempt to clarify the physiology and suggest possible clinical uses. Sixty-six subfertile male patients with varicocele (n = 22). infection of accessory genital glands (n = 14), varicocele plus infection (n = 4), chronic epididymitis (n = 8). post-renal transplantation status (n = 5), idiopathic oligoasthenoteratospermia (n = 9), cryptorchidism (n = 1), and homozygous beta-thalassemia (n = 3) as well as 5 male controls were studied through history, physical examination, spermiograms, plasma basal hormonal levels, and IL-1beta and TNF-alpha levels in seminal fluid. There was no significant statistical difference regarding IL-1beta and TNF-alpha among fertile men and subfertile patients of any cause. 1L-1beta and TNF-alpha were in tight positive correlation (p<.001). Determination of IL-1beta and TNF-alpha does not provide useful information in male routine infertility workup. Nevertheless, a better understanding of these mediators in semen of normal men and infertile patients may contribute to a new approach to the management of male infertility.
Related Links	http://www.tandfonline.com/doi/pdf/10.1080/014850102317267418?needAccess=true
Ending Page	113
Page Count	7
Starting Page	107
ISSN	01485016
e-ISSN	15210375
DOI	10.1080/014850102317267418
Journal	Archives of andrology
Issue Number	2
Volume Number	48
Language	English
Publisher	Informa UK Limited
Publisher Date	2002-01-01
Access Restriction	Open
Subject Keyword	Journal: Archives of andrology Peripheral Vascular Disease Interleukin-1 Beta Seminal Fluid Tumor Necrosis Factor Alpha
Content Type	Text
Subject	Endocrinology

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