NDLI: Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases

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Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases

Content Provider	Scilit
Author	Checler, Frédéric Goiran, Thomas Costa, Cristine Alves Da
Copyright Year	2017
Description	Journal: Autophagy Autophagic and mitophagic defects are consistently observed in Alzheimer's disease-affected brains. However, the mechanistic defects underlying these anatomical lesions remained unexplained. We have delineated a molecular cascade by which PSEN1 and PSEN2 (presenilins 1 and 2) control PINK1 transcription and function by an AICD-mediated FOXO3a-dependent mechanism. Further, we establish that PARK2 (parkin) acts upstream to PINK1 and regulates its function by a PSEN-dependent mechanism. Our study thus demonstrates a functional interplay between PSEN and PINK1 and establishes a feedback process by which PARK2 and PINK1 could control mitochondrial dysfunction and autophagic processes in various neurodegenerative pathologies including Alzheimer's and Parkinson's diseases.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788489/pdf
Ending Page	2005
Page Count	2
Starting Page	2004
ISSN	15548627
e-ISSN	15548635
DOI	10.1080/15548627.2017.1363950
Journal	Autophagy
Issue Number	11
Volume Number	13
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-11-02
Access Restriction	Open
Subject Keyword	Journal: Autophagy Cell Biology Alzheimer Disease Foxo3/foxo3a Park2/parkin Parkinson Disease Transcription Transgenic Mice
Content Type	Text
Subject	Cell Biology Molecular Biology

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