NDLI: Role of Calcium in Biphasic Immunomodulation by γ-Hch (Lindane) In Mice

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Role of Calcium in Biphasic Immunomodulation by γ-Hch (Lindane) In Mice

Content Provider	Scilit
Author	Meera, P. Tripathi, O. Kamboj, K. K. Rao, P. R.
Copyright Year	1993
Description	Journal: Immunopharmacology and Immunotoxicology Gamma-HCH (Lindane) is reported to cause a biphasic immunomodulation-stimulation followed by suppression-after oral administration in mice. Role of calcium in this biphasic immunomodulation was assessed after 4, 12 and 24 wks of gamma-HCH administration. 45Ca-uptake was enhanced during the initial immunostimulation followed by decrease concomitant with immunosuppression. Lymphocyte proliferation was inhibited during both the phases of immune response by verapamil, a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor. These findings show an impairment of calcium homeostasis in lymphocytes culminating into the biphasic immunomodulatory effects of gamma-HCH.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08923979309066937
Ending Page	129
Page Count	17
Starting Page	113
ISSN	08923973
e-ISSN	15322513
DOI	10.3109/08923979309066937
Journal	Immunopharmacology and Immunotoxicology
Issue Number	1
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Journal: Immunopharmacology and Immunotoxicology Endocrinology and Metabolism Biphasic Immunomodulation Immunosuppression Calcium in Biphasic
Content Type	Text
Subject	Immunology and Allergy Toxicology Pharmacology Immunology

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