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Urinary Dopamine and Sodium Excretion in Spontaneously Hypertensive Rats
| Content Provider | Scilit |
|---|---|
| Author | Stier, Charles T. Itskovitz, Harold D. Chen, Yih-Huey |
| Copyright Year | 1993 |
| Description | Journal: Clinical and Experimental Hypertension We measured urinary dopamine in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) before (days 0–6) and during high-salt diet, in the absence (days 6–10) and presence (days 10–14) of added L-dopa (2 mg/kg/day by gavage). Urinary excretion of sodium (UNaV) increased 20-fold during intake of chow containing 8% NaCl in both strains. Systolic blood pressure (SBP) of SHR increased slightly (9.4 mmHg; p<0.05) on the high-salt diet, whereas SBP did not change in WKY. Urinary dopamine excretion was not different between strains in the basal state, and was as great or greater in SHR than WKY during high-salt intake with and without added L-dopa. SBP was unaffected by L-dopa administration and UNaV did not increase or differ between strains despite higher urinary. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10641969309041614 |
| Ending Page | 123 |
| Page Count | 19 |
| Starting Page | 105 |
| ISSN | 10641963 |
| e-ISSN | 15256006 |
| DOI | 10.3109/10641969309041614 |
| Journal | Clinical and Experimental Hypertension |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1993-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical and Experimental Hypertension Peripheral Vascular Disease Urinary Dopamine Sodium and Water Excretion Blood Pressure Spontaneously Hypertensive Rats |
| Content Type | Text |
| Subject | Physiology Internal Medicine |
