Loading...
Please wait, while we are loading the content...
Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide: Clinical and Basic Studies
| Content Provider | Scilit |
|---|---|
| Author | Zhao, Wei-Li Chen, Sai-Juan Shen, Yang Xu, Lan Cai, Xun Chen, Guo-Qiang Shen, Zhi-Xiang Chen, Zhu Wang, Zhen-Yi |
| Copyright Year | 2001 |
| Description | Journal: Leukemia & Lymphoma Arsenic trioxide $(As_{2}O_{3}$) has recently been identified as an effective drug in the treatment of newly diagnosed and relapsed acute promyelocytic leukemia (APL) without cross-resistance to all-trans retinoic acid and achieved complete remission rates of 80–90% according to most reports. With intravenous infusion at a dose of 0.08–0.16 mg/kg daily, a course of 28–42 days is required to induce remission. $As_{2}O_{3}$ in combination with chemotherapy as postremission therapy results in longer survival than arsenic alone. In vitro, $As_{2}O_{3}$ exerts dose-dependent dual effect; triggering apoptosis at relatively high concentration (0.5–2.0 μmol/1), which is associated with the disruption of mitochondrial transmembrane potentials, while inducing partial differentiation at low concentration (0.1–0.5 μmol/1), which might be related to retinoic acid signaling pathway. Importantly, at both concentrations, $As_{2}O_{3}$ can degrade PML (promyelocytic leukemia)-RARα (retinoic acid receptor), an oncoprotein that has a central role in leukemogenesis. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428190109097751 |
| Ending Page | 1273 |
| Page Count | 9 |
| Starting Page | 1265 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428190109097751 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 6 |
| Volume Number | 42 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Acute Promyelocytic Leukemia Arsenic Trioxide Clinical Studies |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
