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Carboplatin and Etoposide (Care) Combined with Radiotherapy and Vincristine, Doxorubicin and Cyclophosphamide (Vac) In Limited Small Cell Lung Cancer a Phase Ii Study
| Content Provider | Scilit |
|---|---|
| Author | Viren, Markku Liippo, Kari Ojala, Antti Helle, Leena Jakobson, Matti Järvinen, M. Paloheimo, Soile Salomaa, Eija-Rhtta Salmi, Reijo Nikkanen, Vaüinämö Jaürvinen, Markku |
| Copyright Year | 1992 |
| Description | Journal: Acta Oncologica Sixty-eight patients with limited small cell lung cancer were treated between April 1988 and October 1990 with combination carboplatin 450 mg/m2 i.v. on day 1 and etoposide 100 mg/m2 i.v. on days 1-3 (CarE) for two courses, followed by thoracic radiotherapy (TRT) 50 Gy, and then vincristine 1 mg/m2, doxorubicin 50 mg/m2 and cyclophosphamide 750 mg/m2 on day one (VAC) for four courses. Prophylactic cranial irradiation (30 Gy) was given to patients with CR after completion of chemotherapy. Sixty patients (89%) achieved an objective response (40% complete responses). The median time to progression was 8.5 months and median survival time 12.1 months. Predicted one- and two-year survival was 50% and 12% respectively. Myelosuppression was the main toxicity, with WHO grade 3 and 4 leukopenia occurring in 32% of VAC courses. There were 5 (7%) treatment-related deaths, all of them during VAC. We conclude that the present combination is active in terms of response rate, but it did not demonstrate any superiority in survival. The frequency of haematological toxicity was substantial during VAC courses. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/02841869209083867 |
| Ending Page | 765 |
| Page Count | 5 |
| Starting Page | 761 |
| ISSN | 0284186X |
| e-ISSN | 1651226X |
| DOI | 10.3109/02841869209083867 |
| Journal | Acta Oncologica |
| Issue Number | 7 |
| Volume Number | 31 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1992-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oncologica Radiology, Nuclear Medicine and Imaging Radiotherapy Cyclophosphamide |
| Content Type | Text |
| Subject | Radiology, Nuclear Medicine and Imaging Hematology Oncology |
