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Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
| Content Provider | Scilit |
|---|---|
| Author | Alcalay, Roy N. Mejia-Santana, Helen Tang, Ming X. Rakitin, Brian Rosado, Llency Ross, Barbara Verbitsky, Miguel Kisselev, Sergey Louis, Elan D. Comella, Cynthia L. Colcher, Amy Jennings, Danna Nance, Martha A. Bressman, Susan Scott, William K. Tanner, Caroline Mickel, Susan F. Andrews, Howard F. Waters, Cheryl H. Fahn, Stanley Côte, Lucien J. Frucht, Steven J. Ford, Blair Rezak, Michael Novak, Kevin Friedman, Joseph H. Pfeiffer, Ronald Marsh, Laura Hiner, Bradley Siderowf, Andrew Ottman, Ruth Clark, Lorraine N. Marder, Karen S. Caccappolo, Elise |
| Copyright Year | 2010 |
| Description | Journal: Journal of Clinical and Experimental Neuropsychology While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911493/pdf |
| Ending Page | 779 |
| Page Count | 5 |
| Starting Page | 775 |
| ISSN | 13803395 |
| e-ISSN | 1744411X |
| DOI | 10.1080/13803390903521018 |
| Journal | Journal of Clinical and Experimental Neuropsychology |
| Issue Number | 7 |
| Volume Number | 32 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-02-24 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Clinical and Experimental Neuropsychology Behavioral Sciences Leucine-rich Repeat Kinase-2 Glucocerebrosidase Mini-mental State Examination |
| Content Type | Text |
| Subject | Neurology Neurology (clinical) Clinical Psychology Neuropsychology and Physiological Psychology |
