Pharmacokinetics of Methotrexate and 7-Hydroxy-Methotrexate after High-Dose (33.6 g/m2) Methotrexate Therapy

Content Provider	Scilit
Author	Slørdal, Lars Kolmannskog, Svein Prytz, Per S. Moe, Peter Johan Aarbakke, Jarle
Copyright Year	1986
Description	Journal: Pediatric hematology and oncology We have measured MTX and 7-OH-MTX in plasma and urine samples from a 9-year-old boy treated with six consecutive 24-h IV high-dose MTX courses (33.6 g/m2) after a relapse of ALL. The between-course pharmacokinetics of MTX and 7-OH-MTX were found to be highly reproducible. Both MTX and 7-OH-MTX elimination followed a biphasic curve, initial half-lives (t1/2(α)) being 2.86 ± 0.44 h and 5.14 ± 0.46 h (mean ± SD) and second-phase biological half-lives (t1/2(β)) being approximately 18 and 16 h, respectively. The apparent volume of distribution for MTX was 0.8 L/kg, whereas the corresponding value for 7-OH-MTX was threefold less. Since clearance of MTX was within the range reported for lower doses, the data suggest that MTX pharmacokinetics are not dose-dependent up to 33.6 g/m.2
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08880018609031208
Ending Page	134
Page Count	8
Starting Page	127
ISSN	08880018
e-ISSN	15210669
DOI	10.3109/08880018609031208
Journal	Pediatric hematology and oncology
Issue Number	2
Volume Number	3
Language	English
Publisher	Informa UK Limited
Publisher Date	1986-01-01
Access Restriction	Open
Subject Keyword	Journal: Pediatric hematology and oncology Pharmacology and Pharmacy Pharmacokinetics Methotrexate Therapy Hydroxy Methotrexate Methotrexate After High
Content Type	Text
Subject	Hematology Pediatrics, Perinatology and Child Health Oncology