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Intensified treatment of hyperphosphatemia associated with reduction in parathyroid hormone in patients on maintenance hemodialysis
| Content Provider | Scilit |
|---|---|
| Author | Chen, Lan He, Jin-Xuan Chen, Ying-Ying Ling, Yi-Sheng Lin, Chun-Hua Guan, Tian-Jun |
| Copyright Year | 2018 |
| Description | This study investigated the therapeutic effect of intensive phosphorus-lowering therapy on intact-parathyroid hormone (iPTH) levels in hemodialysis patients.Ninety-five hemodialysis patients with serum phosphorus ≥1.78 mmol/L and iPTH ≥300 pg/dL were apportioned to either the treatment or control group (n = 43 and 52, respectively) based on patient commitment to treatment. The treatment group was given phosphorus-lowering therapies with phosphate binders (lanthanum, sevelamer or/and calcium reagent) combined with dietary phosphate restriction and intensified hemodialysis. The control individuals were given low doses of calcium agents, if serum calcium was 20% decrease in serum phosphorus, the patients in the treatment group were further stratified as rapid responders (≤2 months; 27 patients) or slow responders (>2 months; 16 patients) and percent changes in iPTH were compared.Serum phosphorus and iPTH levels decreased from baseline in the treatment group (-24.08 ± 1.93% and -9.92 ± 3.70%, respectively) but increased in the control group (22.00 ± 3.63% and 104.21 ± 23.89%; both p < .001). In the rapid responders subgroup, the iPTH decreased (-16.93 ± 3.49%), but in the slow responders subgroup the iPTH increased slightly (0.68 ± 7.37%, p < .05).For these patients on maintenance hemodialysis, intensive treatment of hyperphosphatemia was associated with a decrease in iPTH levels, especially for those who had achieved substantial reduction in serum phosphorus within 2 months. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2017.1419966?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014480/pdf |
| Ending Page | 21 |
| Page Count | 7 |
| Starting Page | 15 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.1080/0886022x.2017.1419966 |
| Journal | Renal Failure |
| Issue Number | 1 |
| Volume Number | 40 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-10-15 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Serum Phosphorus Chronic Kidney Disease Hemodialysis Hyperphosphatemia Parathyroid Hormone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
