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LINCing complex functions at the nuclear envelope
| Content Provider | Scilit |
|---|---|
| Author | Rothballer, Andrea Schwartz, Thomas U. Kutay, Ulrike |
| Copyright Year | 2013 |
| Description | Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements. The complexes are built from members of two evolutionary conserved families of transmembrane (TM) proteins, the SUN (Sad1/UNC-84) domain proteins in the inner nuclear membrane (INM) and the KASH (Klarsicht/ANC-1/SYNE homology) domain proteins in the outer nuclear membrane (ONM). In the lumen of the NE, the SUN and KASH domains engage in an intimate assembly to jointly form a NE bridge. Detailed insights into the molecular architecture and atomic structure of LINC complexes have recently revealed the molecular basis of nucleo-cytoskeletal coupling. They bear important implications for LINC complex function and suggest new potential and as yet unexplored roles, which the complexes may play in the cell. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/nucl.23387?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585024/pdf |
| Ending Page | 36 |
| Page Count | 8 |
| Starting Page | 29 |
| ISSN | 19491034 |
| e-ISSN | 19491042 |
| DOI | 10.4161/nucl.23387 |
| Journal | Nucleus |
| Issue Number | 1 |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Linc Complex Sun Domain Kash Domain Nuclear Envelope Mechanotransduction Nuclear Membrane Spacing Spermatogenesis Nuclear Pore Complex Spindle Pole Body Membrane Fusion |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
