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Platelet-Rich Plasma-Derived Growth Factor vs Hyaluronic Acid Injection in the Individuals with Knee Osteoarthritis: A One Year Randomized Clinical Trial
| Content Provider | Scilit |
|---|---|
| Author | Raeissadat, Seyed Ahmad Ahangar, Azadeh Gharooee Rayegani, Seyed Mansoor Sajjadi, Mohammadreza Minator Ebrahimpour, Adel Yavari, Pegah |
| Copyright Year | 2020 |
| Description | Objective: In this study, we aimed at performing a comparison between intra-articular injections of PRP-derived growth factor (PGRF) and hyaluronic acid regarding their effect on pain and patient's function in knee osteoarthritis, as well as their safety profiles. Methods: During our single-masked randomized clinical trial, the candidates with symptomatic knee osteoarthritis received two intra-articular injections of PRGF with 3 weeks apart or received three weekly injections of HA. The mean improvements from before treatment until the second, sixth, and twelfth months post-intervention in scores obtained by visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index were our primary outcomes. Results: A total of 102 candidates were finally included in the study. Patients' mean age was 57.08± 7.3 years old in the PRGF group compared to the mean age of 58.63± 7.09 years old in HA patients. In the PRGF group, total WOMAC index decreased from 41.96± 11.71 to 27.10± 12.3 (P = 0.02), and from 39.71± 10.4 to 32.41± 11.8 in the HA group after 12 months (P > 0.05). Regarding the Lequesne index, pain, ADL, and global scores significantly decreased after 12 months in the PRGF group compared to the HA group (P< 0.001). There was also a meaningful higher rate of satisfaction in the PRGF group compared to the HA group after 12 months of treatment (P< 0.001). Conclusion: Besides significantly higher satisfaction belonging to the PRGF group, there was a statistically significant improvement in VAS score and global, pain, and ADL score of Lequesne by passing 12 months from injection in PRGF compared to HA. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354951/pdf https://www.dovepress.com/getfile.php?fileID=59536 |
| Ending Page | 1711 |
| Page Count | 13 |
| Starting Page | 1699 |
| ISSN | 11787090 |
| DOI | 10.2147/jpr.s210715 |
| Journal | Journal of Pain Research |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-07-01 |
| Access Restriction | Open |
| Subject Keyword | Prp-derived Growth Factor Hyaluronic Acid Intra-articular Injections Osteoarthritis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
