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Network-based approach to identify prognostic biomarkers for estrogen receptor–positive breast cancer treatment with tamoxifen
| Content Provider | Scilit |
|---|---|
| Author | Liu, Rong Guo, Cheng-Xian Zhou, Hong-Hao |
| Copyright Year | 2015 |
| Description | This study aims to identify effective gene networks and prognostic biomarkers associated with estrogen receptor positive (ER+) breast cancer using human mRNA studies. Weighted gene coexpression network analysis was performed with a complex ER+ breast cancer transcriptome to investigate the function of networks and key genes in the prognosis of breast cancer. We found a significant correlation of an expression module with distant metastasis-free survival (HR = 2.25; 95% CI .21.03–4.88 in discovery set; HR = 1.78; 95% CI = 1.07–2.93 in validation set). This module contained genes enriched in the biological process of the M phase. From this module, we further identified and validated 5 hub genes (CDK1, DLGAP5, MELK, NUSAP1, and RRM2), the expression levels of which were strongly associated with poor survival. Highly expressed MELK indicated poor survival in luminal A and luminal B breast cancer molecular subtypes. This gene was also found to be associated with tamoxifen resistance. Results indicated that a network-based approach may facilitate the discovery of biomarkers for the prognosis of ER+ breast cancer and may also be used as a basis for establishing personalized therapies. Nevertheless, before the application of this approach in clinical settings, in vivo and in vitro experiments and multi-center randomized controlled clinical trials are still needed. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/15384047.2014.1002360?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622923/pdf |
| Ending Page | 324 |
| Page Count | 8 |
| Starting Page | 317 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.1080/15384047.2014.1002360 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 2 |
| Volume Number | 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Informatics Biomarker Breast Cancer Gene Expression Profiling Systems Biology Tamoxifen Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
