NDLI: Cell Cycle Progression without Cyclin D-CDK4 and Cyclin D-CDK6 Complexes

Content Provider	Scilit
Author	Kozar, Katarzyna Sicinski, Piotr
Copyright Year	2005
Description	D-type cyclins (cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the selected cell types. Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
Related Links	http://www.tandfonline.com/doi/pdf/10.4161/cc.4.3.1551?needAccess=true
Ending Page	391
Page Count	4
Starting Page	388
ISSN	15384101
e-ISSN	15514005
DOI	10.4161/cc.4.3.1551
Journal	Cell Cycle
Issue Number	3
Volume Number	4
Language	English
Publisher	Informa UK Limited
Publisher Date	2005-02-01
Access Restriction	Open
Subject Keyword	Cell Biology Developmental Biology Proliferation Cell Cycle Cyclin D Cdk4 Cdk6 Complexes Fashion Cells Can Proliferate
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine Molecular Biology

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Cell Cycle Progression without Cyclin D-CDK4 and Cyclin D-CDK6 Complexes