NDLI: The Life History of Poly(ADP-ribose)

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The Life History of Poly(ADP-ribose)

Content Provider	Scilit
Author	Ikejima, Miyoko Sawada, Yosuke Dang, An Quoc Suhadolnik, Robert J. Gill, D. Michael
Copyright Year	2020
Description	We present arguments and data in support of the following sequence of events in ghost cells. 1) Poly(ADP-ribose, ADPR) synthetase, activated by binding to DNA at a break or other anomaly, synthesizes chains of polymer upon itself, adding new residues at the proximal 1″ terminus of the growing chain. 2) Free chains of poly(ADPR) are produced by release from the active site or by internal glycohydrolysis of the growing chains without hindering the continued elongation. Subsequent glycohydrolysis cuts the free chains down to monomers. 3) ADP-ribosylation of core histones may involve soluble intermediates of some form. Glycohydrolysis generates a limit digest with only short histone-bound chains. 4) Most ADP-ribosylation of histone HI occurs by the addition of single free ADPR residues independently of poly(ADPR) synthetase. Book Name: ADP-Ribosylation, DNA Repair and Cancer
Related Links	https://content.taylorfrancis.com/books/download?dac=C2012-0-01963-4&isbn=9781003079491&doi=10.1201/9781003079491-15&format=pdf
Ending Page	140
Page Count	12
Starting Page	129
DOI	10.1201/9781003079491-15
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-07-26
Access Restriction	Open
Subject Keyword	Book Name: Adp-ribosylation, Dna Repair and Cancer Biochemistry and Molecular Biology Cell Biology Chains Histone Synthetase Adp Ribose Ribosylation Glycohydrolysis
Content Type	Text
Resource Type	Chapter

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