Loading...
Please wait, while we are loading the content...
Diagnostic Value of Serum lncRNA HOTAIR Combined with Galectin-3 in Benign and Papillary Thyroid Carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Li, Li Wang, Jianjun Li, Zhongquan Qiu, Shuang Cao, Junyu Zhao, Yuan Huang, Zhenfan He, Jie Luo, Feipeng Yang, Kunxian |
| Copyright Year | 2021 |
| Description | Purpose: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. LncRNA HOTAIR (HOx Transcript AntIsense RNA) and Galectin-3 are involved in PTC. This study explored the clinical effect of lncRNA HOTAIR/Galectin-3 on PTC patients. Methods: Subjects were assigned into PTC (160 cases) and benign thyroid tumor groups (150 cases). Fasting peripheral venous blood was collected. LncRNA HOTAIR/Galectin-3 expressions in serum were detected. Subjects were assigned into HOTAIR/Glactin-3 high/low expression groups and their correlation with age, gender, BMI, tumor size, pathological stage, TSH, TPO-Ab, and TG-Ab in PTC was analyzed. Receiver operating characteristic (ROC) curve was conducted on diagnostic efficacy of HOTAIR or/and Galectin-3. The difference of area under the curve (AUC) was compared and analyzed. Results: HOTAIR and Glactin-3 were higher in PTC group and correlated with tumor pathological stage. Higher HOTAIR/Glactin-3 expression indicated a more advanced TNM stage. LncRNA HOTAIR was positively correlated with TPO-Ab and TG-Ab. AUC of HOTAIR for PTC diagnosis was 0.895, with 96.00% specificity and 80.63% sensitivity. AUC of Glactin-3 for PTC diagnosis was 0.817, with 66.67% specificity and 78.75% sensitivity. AUC of HOTAIR combining with Glactin-3 for PTC diagnosis was 0.969 with 96.00% specificity and 87.50% sensitivity. AUC of lncRNA HOTAIR was higher than that of Glactin-3, while AUC of the combination was higher than that of lncRNA HOTAIR or Glactin-3. Conclusion: LncRNA HOTAIR and Glactin-3 were highly expressed in PTC. The combination detection of lncRNA HOTAIR/Glactin-3 had higher diagnostic efficiency on the differential diagnosis of benign thyroid tumor and PTC. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=72770 |
| Ending Page | 6525 |
| Page Count | 9 |
| Starting Page | 6517 |
| ISSN | 11791322 |
| DOI | 10.2147/cmar.s312784 |
| Journal | Cancer Management and Research |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-08-01 |
| Access Restriction | Open |
| Subject Keyword | Oncology Lncrna Hotair Thyroid Hotair Combined Efficacy Glactin Differential |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
