NDLI: Suppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells

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Suppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells

Content Provider	Scilit
Author	X-Lan, Mo Z-Lan, Su F-Cheng, Zhang Dan, He H-Qiong, Lu
Copyright Year	2008
Description	Extranodal nasal-type NK cell lymphoma (ENKL) is a high-grade malignancy and associated with EBV latent infection. An optimal therapy has not been discovery. Here, we investigated whether cell proliferation was inhibited by silencing Epstein-Barr virus nuclear antigen 1 (EBNA1) using RNA interference (RNAi ) method in an EBV-positive ENKL cell line, HANK1 cells. We found that silencing EBNA1 expression by RNAi strategy inhibited cell growth and increased the expression of p27 protein and caused cell cycle arrest at G1- phase in HANK1 cells. In conclusions, low-level expression of p27 protein may partially attribute to latent EBV infection in ENKL. EBNA1 may be a good target for the treatment of EBV associated ENKL.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cbt.7.10.6564?needAccess=true
Ending Page	1606
Page Count	5
Starting Page	1602
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.7.10.6564
Journal	Cancer Biology & Therapy
Issue Number	10
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2008-10-01
Access Restriction	Open
Subject Keyword	Virology Protein Antigen Optimal Cell Lymphoma Ebv Latent Latent Ebv Infection
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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