hnRNP and hnRNP-Like Proteins in Splicing Control: Molecular Mechanisms and Implication in Human Pathologies

Content Provider	Scilit
Author	Lorkovic, Zdravko
Copyright Year	2012
Description	The heterogeneous nuclear ribonucleoprotein (hnRNP) family includes a diverse group o f RNA binding proteins to which we are affiliating here other structurally and functionally related proteins (e.g., Nova, Sam68, ESRP, Fox, TDP-43, Hu, CUG-BP, M BN L and TIA proteins). These hnRNP and hnRNP-like proteins make important contributions to protein diversity and activity by modulating the alternative splicing o f a large repertoire o f pre-mRNAs. They achieve this function through a variety o f molecular strategies ranging from direcdy preventing the recognition o f splice sites, antagonizing or helping the assembly o f positive regulatory complexes, interfering with spliceosome assembly and changing the conformation o f pre-mRNAs. In addition to regulating key splicing events, defects in the expression o f these proteins are now being documented for a growing number o f human diseases including cancer. hnRNP and hnRNP-like proteins therefore represent a group ofproteins whose roles in the control o f splicing pervade all areas ofbiology and human health. Book Name: RNA Binding Proteins
Related Links	https://content.taylorfrancis.com/books/download?dac=C2014-0-36248-4&isbn=9780429090073&doi=10.1201/9781498713368-7&format=pdf
Ending Page	38
Page Count	26
Starting Page	13
DOI	10.1201/9781498713368-7
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-08-10
Access Restriction	Open
Subject Keyword	Book Name: Rna Binding Proteins Cell Biology Function Diversity Splicing Structurally Changing the Conformation Like Proteins Hnrnp Like
Content Type	Text
Resource Type	Chapter