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An RB insensitive to CDK regulation
| Content Provider | Scilit |
|---|---|
| Author | Joaquin, Manel de Nadal, Eulàlia Posas, Francesc |
| Copyright Year | 2016 |
| Description | The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB regulation opens up a window for developing new cancer drug treatments for tumors harboring high CDK-Cyclin activity and a wild-type RB gene. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/23723556.2016.1268242?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286971/pdf |
| ISSN | 23723556 |
| e-ISSN | 23723556 |
| DOI | 10.1080/23723556.2016.1268242 |
| Journal | Molecular & cellular oncology |
| Issue Number | 1 |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-01-02 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Cellular Stress Retinoblastoma Tumor Suppressor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Molecular Medicine |